Gary Sinise became a mainstream movie star and earned an Academy Award and a Screen Actors Guild Award for his portrayal of Lt. Dan in Forrest Gump. He received the Best Supporting Actor Award from the National Board of Review and the Commander's Award from the Disabled American Veterans. He then went on to take starring roles in two films for director Ron Howard in Apollo 13 and Ransom, as well as in Brian DePalma's Snake Eyes. Other recent roles include Robert Benton's The Human Stain and The Big Bounce directed by George Armitage. Upcoming is Michael Apted's Scheherazade with Juliette Binoche.

Sinise was also seen in Gary Fleder's sci-fi thriller Imposter and James D. Stern's ensemble drama All The Rage, as well as John Frankenheimer's Reindeer Games, Brian DePalma's Mission to Mars and Frank Darabont's The Green Mile. His additional film credits include Keith Gordon's A Midnight Clear, Kevin Spacey's directorial debut Albino Alligator, Marshall Herskovitz's Jack The Bear, and Sam Raimi's The Quick And The Dead.

On television, he starred in the cable feature Path To War directed by John Frankenheimer and in the Hallmark Hall of Fame telefilm, Fallen Angel. Other television credits include the cable adaptation of Jason Miller's Pulitzer Prize-winning play That Championship Season directed by Paul Sorvino, the title role in Frank Pierson's Truman (for which he won a Golden Globe, a Cable Ace and a Screen Actors Guild award) and John Frankenheimer's George Wallace for which he won a Screen Actors Guild award, an Emmy and a Cable Ace award, as well as co-starring in My Name is Bill W directed by Daniel Petrie and Stephen King's The Stand directed by Mick Garris.

Sinise took on the roll of Det. Rick Calucci in CBS's CSI: New York produced by Jerry Bruckheimer and Anthony Zuiker.