Wang pitched for the Taiwan Baseball Team in the 2002 Asian Games. In 2004, as the apparent ace of the staff, Wang led Taiwan to the Olympic Games in Athens. Against Australia, he allowed just three hits with no walks, and at one point retired nine batters in row, to earn the victory. He also limited Japan to just five hits in the first six innings; however, the Japanese rallied in the seventh inning against Wang to tie the game with three runs. Japan won the game, preventing Taiwan from advancing to the next round.

He is the third major leaguer from Taiwan, following Dodgers outfielder Chin-Feng Chen and Rockies pitcher Chin-Hui Tsao, and is by far the most successful. Since being called up to the majors, Wang has been idolized in his native country where all of his games are televised nationwide, many on big screens to large audiences. This is still true even though he decided not to pitch in the 2006 World Baseball Classic.

In 2005, Wang was called up from the Yankees' AAA affiliate, the Columbus Clippers. In the first season as a major league player, he earned 8 wins and 5 losses with 4.02 ERA. In addition, he pitched for the first time in a post-season game against the Los Angeles Angels.

On September 19, 2005, Wang tied a record for assists in a game by a pitcher with nine.

On June 3, 2006, Wang recorded his first major league save in a win over the Baltimore Orioles. He recorded his first complete game on June 18, 2006 against the Washington Nationals, but it was a bittersweet accomplishment as he allowed a 1-out, 2-run, walk-off home run by Ryan Zimmerman to lose the game 3-2.

His first complete game win was on July 28, 2006, a 2-hit, 6-0 shutout of the Tampa Bay Devil Rays at Yankee Stadium. In his next start, he threw eight shutout innings against the Toronto Blue Jays, in which he got an outstanding 18 ground ball outs. Were it not for the extreme heat in New York that day, he probably would've had an excellent chance of achieving shutouts in two consecutive starts, an extremely rare feat in this age of heavy emphasis on relief pitching, as he had a 7-0 lead.

Wang had an excellent 2006 season, posting a 19-6 record with a 3.63 ERA along with 76 strikeouts, 407 groundouts and 2.84 ground outs/fly outs Ratio. His 19 wins in 2006 broke the record for wins in a season by an Asian pitcher formerly held by Chan Ho Park. He also was the Yankees Game One starter going into the postseason. The first game of the 2006 postseason against the Detroit Tigers ended up with the score of 8-4. Wang earned his first career postseason win on October 3, 2006, with 6.2 innings of pitching allowing only 3 earned runs. Wang is the first ethnic Asian starting pitcher to have won a post season game. During the 2006 season, he surpassed his total innings pitched in any other season, including those in Major League Baseball and in Taiwan.

At the end of the season Wang finished second to Minnesota Twins ace, Johan Santana in voting for the Cy Young award. Wang collected 15 second-place votes and 51 points.

--Wikipedia